【Objective】 To investigate the expressions of SENP-1 and HIF-1α in hepatocellular carcinoma tissues

tumor-surrounding tissues

and non-cancer tissues

elucidate the correlations between SENP-1

HIF-1α and the occurrence of hepatocellular carcinoma and explore their roles in tumor angiogenesis. 【Methods】 The expressions of SENP-1 and HIF-1?琢 in tumor tissues

tumor-surrounding tissues and non-cancer tissues were assessed by RT-PCR

quantitive PCR and immunohistochemistry in 57 cases with hepatocellular carcinoma. MVD was determined by anti-CD34 immunohistochemical staining

then we studied the relationship between the expressions and the clinicopathologic features. 【Results】 Compared with the non-cancer tissues

the mRNA levels of SENP-1 and HIF-1α in hepatocellular carcinoma tissues and tumor-surrounding tissues were much higher. There were positive expressions of SENP-1 and HIF-1α in hepatocellular carcinoma tissues and tumor-surrounding tissues

and negative expressions in non-cancer tissues. The expressions of SENP-1 and HIF-1α in tumor-surrounding tissues were increased significantly compared with tumor tissues(P<0.05)

and negative correlation with the differentiation degree of tumor tissues. There was positive correlation between the expressions of SENP-1 and HIF-1α in tumor and tumor-surrounding tissues (r = 0.761

P = 0.000; r = 0.346

P = 0.008)

while the expression of HIF-1α was negatively correlated with MVD (r = -0.684

P = 0.000; r = -0.808

P = 0.000). 【Conclusion】 The expressions of SENP-1 and HIF-1α are an important regulation mechanism for hepatoma cells to adapt to hypoxia

and play an important role in hepatocellular carcinoma angiogenesis.