【Objective】 To investigate the relationship of chronic hepatitis C (CHC) patients combined with diabetes mellitus and its related factors. 【Methods】 Clinical data of 200 patients with CHC combined with diabetes mellitus (CHC + DM group) and 242 patients with barely CHC (CHC group) were collected and analyzed

the comparative data including alanine aminotransferase (ALT)

aspartate aminotransferase(AST)

γ-glutamyl (GGT)

total bilirubin (TB)

fasting plasma glucose

fasting insulin blood triglycerides and other related indicators

serum hepatitis C virus (hepatitis C virus

HCV) RNA was also detected. All the clinical data were compared according to the severity of chronic hepatitis C. 【Results】(1) Serum fasting glucose

fasting insulin

insulin resistance index (HOMA-IR)

AST

ALT

and GGT in CHC + DM group were significantly higher than those in CHC group. ② The incidence of liver cirrhosis (24.0% vs 3.3%

P < 0.01)

liver cancer (6.0% vs 0.5%

P < 0.01) and hypertension (29.0% vs 2.1%

P < 0.01) in CHC + DM group was significantly high than those in CHC group. ③CHC patients combined with diabetes mellitus have a positive correlation with age and severity (P < 0.01). The proportion of moderate and severe in CHC + DM group was significantly high than that in CHC group (P < 0.01). The incidence of patients older than 50 years old in CHC + DM group was exceed that in CHC group. ④ Multi-regression analysis showed that age

ALT

GGT

liver cirrhosis

hypertension and insulin resistance index have a positive correlation with CHC patients combined with diabetes mellitus (P < 0.05). 【Conclusion】 Age (> 50 years old)

ALT

GGT

liver cirrhosis

hypertension

HOMA-IR

and liver cancer are intimately correlated with CHC patients combined with diabetes mellitus.