【Objective】 To investigate clinical significance of gestational diabetes mellitus (GDM) by detecting the level of homocysteine. 【Methods】 A total of 153 cases of GDM gravida were selected as observation group in Huzhou Women?蒺s and Children?蒺s Hospital from May 2012 to August 2012

and they were divided into group A1 and A2 according to the blood glucose level. 90 cases healthy pregnant women were selected as control group during the same period. Serum homocystein concentration was studied of all the cases

and the correlation between homocysteine and pregnancy outcomes was analyzed. 【Results】 The serum HCY level in group A2 (11.98 ± 4.05) was significantly higher than that in group A1(8.88 ± 2.63) and control group (8.86 ± 2.48) (P < 0.01). Univariate analysis showed that age

weight

parity

gestational age

HCY

fasting blood glucose affect the incidence of maternal and infant adverse outcomes of pregnancy. Logistic regression analysis revealed that the gestational age and HCY are independent factors influence the outcome of pregnancy. 【Conclusion】 Serum homocysteine level is closely related to the development of gestational diabetes and pregnancy outcome. Monitoring blood HCY may be more help to determine the risk of the occurrence of adverse outcomes of gestational diabetes mellitus than monitoring single blood glucose.