网络首发:2012-11-20,
纸质出版:2012
移动端阅览
子宫内膜癌患者代谢综合征及其组分发病情况[J]. 中山大学学报(医学科学版), 2012,33(6).
Prevalence of Metabolic Syndrome and Its Components in Chinese Womenwith Endometrial Cancer[J]. Journal of Sun Yat-sen University (Medical Sciences), 2012, 33(6).
【目的】 探讨子宫内膜癌患者代谢综合征(MS)及其组分的发病情况,并与健康体检人群进行比较。【方法】 选取2005年9月至2009年12月在中山大学孙逸仙纪念医院妇科肿瘤专科进行初始治疗的子宫内膜癌患者265例为研究组,用年龄及绝经与否进行匹配的同期在我院体检中心进行体检的女性265例为对照组,对其临床资料进行回顾性分析。代谢综合征的诊断采用2005年国际糖尿病联盟制定的标准。【结果】 研究组MS发病率为41.89%,对照组MS的发病率为9.28%;研究组的腰围、BMI、收缩压、舒张压、TG、FPG水平均高于对照组,HDL- C水平低于对照组;研究组代谢异常的发生率从高到低是低HDL-C(55.09%)、高SDP(44.53%)、高TG(35.09%)、高BMI(34.72%)、高DBP(27.92%)和高FPG(26.04%);研究组合并代谢综合征0~5个组分的比例分别为:13.96%、24.53%、16.23%、20.75%、18.11%和6.42%;研究组中两个年龄段亚组MS发病率无差异,4个BMI亚组MS发病率分别为0、21.18%、79.55%和100%;多因素分析显示,腰围、DBP、TG是子宫内膜癌合并MS的独立危险因素;研究组是否合并MS患者的病理类型、分期差异无统计学意义,但病理分化程度中高分化组与中分化组所占比例差异有统计学意义。【结论】子宫内膜癌与代谢综合征及其组分关系密切,这可能为子宫内膜癌的防治提供一条新思路。
【Objective】 To study the prevalence of metabolic syndrome (MS) and its components in Chinese women with endometrial cancer and compared with these characteristic with healthy controls. 【Methods】 A retrospective study was conducted on 265 patients who were admitted in Department of Gynecology Oncology, the Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (study group) and 265 healthy women (control group) with matching age and menopause condition from September 2005 to December 2009. International Diabetes Federation criteria for MS were used. 【Results】 The prevalence of MS were 41.89% in study group and 9.28% in control group. The univariate survival analysis showed that there were significant difference with the size of waist circumference, the level of BMI, SDP, BDP, TG, FPG, and HDL-C in the two groups. The order of metabolic abnormity in study group from high to low were HDL-C (55.09%), SDP (44.53%), TG (35.09%), BMI (34.72%), DBP (27.92%), and FPG (26.04%). The rate of combing 0 to 5 MS’s components in study group were 13.96%, 24.53%, 16.23%, 20.75%, 18.11%, and 6.42%, respectively. In study group, the prevalence of MS was not significant difference for two age groups; the prevalence of MS were 0, 21.18%, 79.55%, and 100% for four different BMI groups respectively. The Logistic multivariate survival analysis shown that the size of waist circumference, the level of BDP and TG were independent risk factors for endometrial cancer coupled with MS. There were not significant difference for the pathological type, low grade, clinical stage between patients with or without MS in study group apart from the high and middle grade pathological type. 【Conclusion】 High prevalence of MS and its components was found in women with endometrial cancer compared with age- and menopause-matched controls in this study. Metabolic syndrome is closely associated with an increased risk of endometrial cancer, which may be the new point to screen, prevention and treatment endometrial cancer.
0
浏览量
503
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621
