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纸质出版:2012
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宫颈腺癌125例预后分析[J]. 中山大学学报(医学科学版), 2012,33(4).
Clinical Analysis of 125 Cases of Cervical Adenocarcinoma[J]. Journal of Sun Yat-sen University (Medical Sciences), 2012, 33(4).
【目的】 总结宫颈腺癌临床病理资料和随访资料
了解宫颈腺癌预后相关因素? 【方法】 回顾性分析中山大学附属第一医院妇科2000 年1 月至2010 年12 月间收治的125 例宫颈腺癌临床病理资料和随访资料?【结果】 125例患者中位年龄45 岁
总的5 年生存率为75.5%
按FIGO 分期Ⅰ?Ⅱ?Ⅲ期患者5年生存率分别为93.4%?66.7%?30.0%?单因素?多因素分析均显示FIGO分期?局部肿瘤大小?组织学分级是影响预后的独立因素?39例II期患者采用不同方法治疗的预后差异无统计学意义(P = 0.122)?102例手术治疗患者
63例行双附件切除
卵巢转移4例
其中ⅡB期1例
Ⅲ期3例;39例保留单侧或双侧卵巢患者随访中
2例发生卵巢转移
本组经病理确诊的卵巢转移率为5.9%(6/102)?卵巢保留与否者的5年生存率无统计学差异(P > 0.05)?本组25例临床检查宫颈外观正常者宫颈液基细胞学检查20例(80%)异常
5例(20%)正常?【结论】 FIGO分期晚?局部肿瘤直径 > 4 cm?肿瘤细胞分化差的患者预后较差?根治性手术或以根治性手术为主的综合治疗是治疗宫颈腺癌的主要方法
早期年轻宫颈腺癌患者可考虑保留卵巢功能?宫颈液基细胞学检查有助于无症状体征宫颈腺癌患者的早期诊断?
【Objective】 To investigate the prognosis of cervical adenocarcinoma by analyzing the clinical and follow-up data.【Methods】 Clinical and pathological data of 125 cases of cervical adenocarcinoma hospitalized in Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-san University from January 2000 to October 2010 were retrospectively analyzed. 【Results】 Median age of these cases was 45 years. According to FIGO staging system
the overall 5-year survival rate was 75.5%
and it was 93.4%
66.7%
and 30.0% for stages Ⅰ
Ⅱ
and Ⅲ
respectively. The FIGO stages
carcinoma diameter
and grading of tumor were independent factors of the survival rate for cervical adenocarcinoma patients. The prognosis of 39 cases at stages Ⅱ who received different treatments were not statistically significant (P = 0.122). In the 102 surgery cases
63 cases received bilateral accessories resection
4 cases suffered from ovarian metastasis
and one of those was of stage ⅡB
three of those were of stage Ⅲ. However
in the 39 surgery cases preserving ovarian function
2 cases suffered from ovarian metastasis in the work of follow-up. In this study
proportion of ovarian metastasis with pathological diagnosis was 5.9% (6/102). In the surgery patients
whether preserving ovarian function were not statistically significant (P > 0.05). 25 cases with apparently normal cervix uteri received liquid based cytology test and 80% of these cases presented pathological changes.【Conclusions】 Patients with late FIGO stages
carcinoma diameter over 4 cm and poorly differentiation had worse prognosis. Radical hysterectomy and comprehensive therapy involving radical hysterectomy were the main treatments of cervical adenocarcinoma
preserving ovarian function could be applied in young women with early stages. Liquid based cytology test was conducive to early diagnosis of cervical adenocarcinoma with nonspecific signs and symptoms.
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