【Objective】To evaluate the cognitive function of abstinent drug dependent individuals

and understand the modulation effect of working memory on the influence of anxiety on the inhibition of drug dependent individuals. 【Methods】 The Hospital Anxiety and Depression scale (HADS)

continuous performance task and 2back task were adopted to measure the anxiety and depression state

inhibition and working memory of 150 drug dependent individuals as well as 100 nodrug users

who matched with drug dependent subjects in age

gender

and education year

and Raven IQ original score. t test were used to compare anxiety

depression

inhibition and working memory between two groups. Correlation and regression were used to test the modulation effect of working memory on the influence of anxiety on inhibition. 【Results】 Significant difference were found in the anxiety

depression state and working memory (2back accuracy)

inhibition (CPT commission error

CPT reaction time) between drug dependent and control groups (P < 0.05). Working memory was found to have a partmodulation effect on the influence of anxiety on the inhibition. The rate of contribution of working memory was 29.5%. 【Conclusion】 The abstinent drug dependent individuals were found to have deficient working memory and inhibition; anxiety influenced both 2back task accuracy and inhibition. The working memory could modulate the effect of anxiety on the inhibition.