【Objective】 To investigate the relationship between serum HBV DNA loads and liver pathological changes in the patients with chronic hepatitis B. 【Methods】 The relationship among HBV DNA loads

live histological inflammation grades and fibrosis stages of 158 cases was analyzed. 【Results】 The serum HBV DNA loads (lg copies/mL) in HBeAg-positive group with inflammation grades G0~1 (6 patients)

G2 (74 patients) and G3~4 (25 patients) were 5.6 ± 1.1

6.5 ± 2.0 and 7.0 ± 1.5

respectively. There was no significant difference in the patients of three inflammation grades (P = 0.250). The serum HBV DNA loads in HBeAg-positive group with liver tissues fibrosis stages of S0~1 (23 patients)

S2 (56 patients)

S3~4 (26 patients) were 6.6 ± 1.8

6.6 ± 2.0

6.6 ± 1.6

respectively

the difference was not significant (P = 0.996). The serum HBV DNA loads in HBeAg-negative group with inflammation grades G0~1 (8 patients)

G2(17 patients) and G3~4 (28 patients) were 2.1 ± 1.9

4.7 ± 2.2 and 5.6 ± 2.3 respectively. The serum HBV DNA level in patients with G2 and G3~4 inflammation grades was significant higher than in patients with G0~1 inflammation grades (P = 0.001). The serum HBV DNA loads in HBeAg-negative group with liver tissues fibrosis stages of S0~1(10 patients)

S2 (25 patients)

S3~4 (18 patients) were 2.7 ± 3.2

5.1 ± 1.8

5.4 ± 2.4 respectively. The serum HBV DNA level in patients with fibrosis stages of S2 and S3~4 was significant higher than in patients with fibrosis stages of S0~1 (P = 0.005). 【Conclusions】 The serum HBV DNA level does not correlate with the inflammation grades and fibrosis stages of liver tissues in HBeAg-positive patients. The serum HBV DNA loads display a positive correlation with the inflammation grades and fibrosis stages of liver tissues in HBeAg-negative patients.