【Objective】 To compare the effects of pharmacotherapy and surgical intervention in the treatment of adenoid hypertrophy and to make evidence base for standard pharmacotherapy. 【Methods】 83 outpatient children cases with adenoid hypertrophy were randomly divided into two groups (case history >12 weeks): pure pharmacotherapy group (PP group) and surgical intervention group(SP group). Clinical therapeutic effect evaluation was did on 3 months after treatment (pharmacotherapy or surgery + pharmacotherapy) including adenoid size

immunoglobulin levels

effect evaluation of secretory otitis media

children rhinosinusitis and children obstructive sleep apnea and hyponea syndrom. Single sample t-test/two groups of independent sample t test and KruskalWallis Test of orderly classified data were used to compare the clinical therapeutic effect of two groups. 【Results】 There was no statistical difference of adenoid size between the two groups before treatment

but there was statistical difference of adenoid size on 3 months after treatment between two groups(P=0.038). Adenoid size after treatment was statistically different with it before treatment in each group (P=0.000). IgA

IgG

and IgM levels before treatment were no statistically different with its after treatment of 3 months in each group (P>0.05). There were no statistic differences between two groups when effects of secretory otitis media

children rhinosinusitis

and children obstructive sleep apnea and hyponea syndrom were evaluated by Kruskal Wallis test (P=0.822

0.773

0.559). 【Conclusions】 Pure standard pharmacotherapy could achieve good results. Effects evaluation after 3 months of treatment showed that surgical intervention did not increase therapeutic effect on adenoid hypertrophy. Children patients suffering from adenoid hypertrophy should be treated firstly by pharcotherapy

and surgical intervention should be more cautious and strict.