【Objective】 To analyze the interaction between human platelet alloantigens3 (HPA3) and traditional risk factors in acute myocardial infarction (AMI). 【Methods】 The study consisted of 215 AMI patients

the controls were selected form healthy people. Total genomic DNA was isolated by the phenolchloroform method

and HPA genotyping was done by the polymerase chain reaction method using sequencespecific primers. Meanwhile

regression analysis was applied in assessing the genetic risk factors to AMI. The method of crossover analysis was used to study the interaction between human platelet alloantigens3 and traditional risk factors in AMI. 【Results】 (1) Compared with the control group

the difference of HPA3 gene polymorphism were not statistically significant (P > 0.05). (2) Compared with control group

there were no interaction in HPA3b allele with age (≤60) (OR = 1.361

95%CI = 0.8242.250)

and interaction analysis confirmed the abated negative association of HPA3b allele with smoking (OR=0.238

95%CI 0.130~0.436)

hypertension (OR=0.415

95%CI 0.248 ~ 0.695)

diabetes (OR=0.279

95%CI 0.122~0.640) or dyslipidemia (OR=0.372

95%CI 0.212~0.654). 【Conclusion】There may show abated negative association of the HPA3b allele with smoking

hypertension

diabetes

or dyslipidemia in AMI.