【Objective】 To observe current status of diabetic nephropathy (DN) in Guangdong type 1 diabetic patients and to explore its risk factors. 【Methods】 Demographic and clinical data of type 1 diabetic patients diagnosed since Jan 1

2000 were collected by a provincial-wide registry database. Blood and urine samples were also collected. Glycosylated hemoglobin A1c

(HbA1c) and urine albumin creatinine ratio (UACR) values were measured centrally. Patients were divided into 3 groups according to UACR values: normoalbuminuria

microalbuminuria

and macroalbuminuria. Multivariate logistic regression analysis was performed to assess correlates of DN. 【Results】 A total of 814 patients were enrolled from August 2010 to March 2011. The age was 29.4 years (interquartile range 20.2

41.4

and followed same)

duration of T1DM was 3.2 years (0.8

7.2) and HbA1c level was 8.6 % (6.9%

11.0%). Normal UACR

microalbuminuria and macroalbuminuria were observed in 636 (78.1%)

134 (16.5%) and 44 (5.4%) of the patients

respectively. Multivariate logistic regression models showed that the independent risk factors for DN were duration of T1DM

waist-hip ratio (WHR) and HbA1c. 【Conclusion】 A relatively higher proportion of patients (21.9%) was observed in this population. DN in T1DM patients was associated with duration

WHR and HbAlc. There is an urgent need for a more comprehensive management for Guangdong T1DM patients.