【Objective】 To investigate the risk factors associated with the occurrence of neonatal dacryocystitis. 【Methods】 A case-control study was conducted. 150 infants with neonatal dacryocystitis and 150 normal control were screened from patients of Guangzhou Women and Children's Medical Center. The Controls were non-neonatal dacryocystitis infants and their non-investigation factors are the same. The risk factors of neonatal dacryocystitis were analyzed by univariate and multivariate unconditional Logistic regression analysis. 【Results】 Three risk factors were screened to be associated with the occurrence of neonatal dacryocystitis

including Gestational age less than 37 weeks (OR

4

922)

birth mass of more than 4 kg (OR

2.418) and family history of rhinitis (OR

2.453). 【Conclusion:】 Preterm birth

macrosomia and family history of rhinitis are major risk factors contributing to neonatal dacryocystitis in neonates.