Volumetric Modulated Arc Therapy, Conventional Intensity-modulated Radiotherapy and Three-Dimensional Conformal Techniques for Upper Thoracic Esophageal Cancer: A Planning Comparison Study
Volumetric Modulated Arc Therapy, Conventional Intensity-modulated Radiotherapy and Three-Dimensional Conformal Techniques for Upper Thoracic Esophageal Cancer: A Planning Comparison Study[J]. Journal of Sun Yat-sen University (Medical Sciences), 2012, 33(2).
Volumetric Modulated Arc Therapy, Conventional Intensity-modulated Radiotherapy and Three-Dimensional Conformal Techniques for Upper Thoracic Esophageal Cancer: A Planning Comparison Study[J]. Journal of Sun Yat-sen University (Medical Sciences), 2012, 33(2).DOI:
【Objective】 A planning study was performed to compare volumetric modulated arc therapy (VMAT)
static intensity-modulated radiotherapy (sIMRT)
and three-dimensional conformal radiotherapy (3DCRT) for upper thoracic esophageal cancer. 【Methods】 Seven patients with loco-regionally advanced upper thoracic esophageal cancer were included. Based on the identical CT and planning target volume (PTV)
three plans (3DCRT
sIMRT with seven fields
VMAT with a single arc) were generated. Dose prescription was set to 60Gy in 30 fractions. Dose volume histograms
MU and delivery time were evaluated to assess plan quality. 【Results】 In comparison to 3DCRT
both VMAT and IMRT provided a systematic improvement in PTV coverage. For normal tissues
equivalent sparing of lung and heart were achieved with three plans. However
IMRT and VMAT showed a superior sparing compared with 3DCRT for spinal cord. The MU/fraction was as follows: 537 ± 92 for 3DCRT
601 ± 122 for IMRT
and 682 ± 139 for VMAT. Effective treatment time for 3DCRT
IMRT and VMAT were (3.9 ± 0.3) min
(6.0 ± 0.7) min and (4.7 ± 0.7)min
respectively (P < 0.05). 【Conclusions】 Compared with 3DCRT
IMRT and VMAT showed better dosimetric quality and superior spinal cord sparing. However
VMAT improved delivery efficiency significantly than IMRT.