【Objective】The structure and properties about encoding protein of the translationally controlled tumor protein (TCTP) from Sporothrix schenckii were analyzed and predicted by bioinformatics. 【Methods】 A full-length cDNA sequence encoding TCTP from cDNA plasid library of Sporothrix schenckii was identified by using tools of bioinformatics at webs sites of NCBI

ExPASy and software DNAstar

VectorNTIsuite. The characteristics of the deduced protein were predicted by employing bioinformatics software package supplied by the website of ExPaSy. 【Results】 A complete open reading frame of 621 bp was included in the full cDNA sequence encoding SS.TCTP. The sequence of TCTP analysis showed that it had high homology in the amino acids sequence from other species in GenBank. The molecular weight of SS.TCTP was predicated to be 64581.4 ku and the coding protein was demonstrated to contain one transmembrane region

three main hydrophilic regions and 5 main B cell epitopes. The relationship of phylogenesis between SS.TCTP and TCTP of other fungus is close. 【Conclusions】 The full-length cDNA sequence encoding TCTP was screened from cDNA library of Sporothrix schenckii bioinformatics and the structure and characteristics of the gene and protein of SS.TCTP as well as the immunological properties were predicted.