【Objective】 Whether snail expression in breast cancer predicts the efficacy of neoadjuvant chemotherapy and prognosis is investigated. 【Method】 Immunohistochemical assay was used to detect the snail protein level of 192 breast cancer tissues obtained by core needle biopsy before neoadjuvant chemotherapy. The relationship of snail expression with clinicopathological characteristics and efficacy as well as prognosis of neoadjuvant chemotherapy was statistically analyzed. 【Results】 High snail expression was associated with larger primary tumor size

more lymph node metastasis

poor clinical response to neoadjuvant chemotherapy

poor disease free survival and overall survival. 【Conclusion】 The protein level of snail shows predictive value of the efficacy of neoadjuvant chemotherapy based on anthracyclines and prognosis in breast cancer.