【Objective】 To understand the effect of interleukin-10 in retinal inflammation

the concentration of IFN-γ (interferon-γ) and TNF-α (tumor necrosis factor-α) in vivo of murine ocular toxoplasmosis. 【Methods】 One hundred and twenty C57BL/6 mice were divided into three groups: forty mice in the control group

forty mice in the infection group (experiment A) and forty mice in the injecting IL-10 group (experiment B). Toxoplasma gondii infected mice by intraperitoneal injection. Histological sections of the three groups were detected. The DNA of Toxoplasma gondii in eyes and serum were detected. The concentration of IFN-γ and TNF-α in eyes and serum were detected in experimental groups. 【Results】 P30 gene could be detected in experiment groups on the sixth day. Compared with the control group

the concentration of IFN-γ (4531.4 pg/mL) and TNF-α (1572.3 pg/mL) in aqueous humor was higher in experiment A group; and the concentration of IFN-γ (456 ± 39 pg/mL) and TNF-α (14.6 ± 2.2 pg/mL) in serum was higher in experiment A group too. Toxoplasm and apparent inflammation were watched in retina. Compared with the experiment A group

the concentration of IFN-γ (2482.7 pg/mL) and TNF-α (1248.1 pg/mL) in aqueous humor was lower in experiment B group

and the concentration of IFN-γ (266 ± 27 pg/mL) and TNF-α (12.1 ± 1.9 pg/mL) in serum was lower in experiment B group too. Mean square analysis about the concentration of IFN-γ and TNF-α in serum was carried out between the three groups. The difference was statistical significance (P < 0.01). Toxoplasm and light inflammation were watched in retina. 【Conclusion】Toxoplasma gondii damaged retina. IL-10 could relieve inflammation of murine ocular toxoplasmosis.