【Objective】 To investigate the clinical characters of nonsteroidal anti-inflammatory drugs (NSAID) associated peptic ulcer bleeding through retrospective analysis. 【Methods】Four hundred ninety-nine patients who were hospitalized in our wards diagnosed as peptic ulcer bleeding from February 2007 to January 2011 were divided into two groups according to taking NSAID or not. 【Results】 Sixty-nine cases (13.8%) with NSAID associated peptic ulcer bleeding were included. Compared with 430 cases without NSAID associated

there were significant differences in age

gender

co-administration with anti-coagulant drugs or steroids

location and amount of ulcers

severity of anemia in elder patients (P<0.05). 【Conclusions】 NSAID associated peptic ulcer bleeding mainly occurred in stomach with more multiple ulcers

while patients seldom complained of epigastric pains. These ulcers were more common in 60-year-old or above patients

who suffered from more severe anemia.