【Objective】 To investigate the effect of low-magnitude high-frequency (LMHF) whole body vibration on bone-implant osseointegration in osteoporotic rats. 【Methods】 Thirty female rats were ovariectomized to induce osteoporosis

and then treated with LMHF vibration (VIB) or alendronate (ALO) or a control treatment (OVX). Another 10 rats were sham operated as Sham control group. Before treatment

hydroxyapatite (HA)-coated titanium implants were inserted into proximal tibiae bilaterally. Both LMHF vibration and alendronate treatment were lasted for 8 weeks. 【Results】 The BMD [(0.228 ± 0.022) g/cm]

maximum push out force [(180 ± 22) N]

interfacial shear strength [(6.5 ± 0.8)N/mm]

bone-implant contact [BIC

(69 ± 4)%] and bone area [BA

(72.7 ± 1.8)%] of group VIB were significant higher than those of group OVX [(0.202 ± 0.022)g/cm

(119 ± 16)N

(4.3 ± 0.6) N/mm

(51 ± 5)%

(45 ± 4)%

respectively;P < 0.05]

but were lower than those of group ALO[(0.254 ± 0.036)g/cm

(224 ± 28) N

(8.3 ± 0.9)N/mm

(83 ± 6)%

(80 ± 3)%)] and Sham [(0.261 ± 0.028) g/cm2

(245 ± 33)N

(8.9 ± 1.2)N/mm

(91 ± 5)%

(89 ± 6)%;P < 0.05]. No significant difference was found between group ALO and Sham. 【Conclusion】 LMHF whole body vibration enhances bone-implant osseointegration in ovariectomized rats

but with less effectiveness when compared with alendronate.