【Objective】To explore the impact of uterine artery embolization (UAE) upon the quantity of endometrial integrin β3 by experiment. 【Methods】Forty-eight female guinea pigs were randomly divided into control group (n=12) and UAE group (n=36

further divided into A1

A2 and A3 subgroup

12/subgroup). The UAE group was performed bilateral uterine artery embolization with trisacryl gelatin microspheres (Embosphere

40-120 µm and 100-300 µm). All the animals were sacrificed and obtained uterine specimens 3 days after ovulation day. The A1

A2

and A3 group were obtained specimens within 16-30

31-45

and 46-60 days

respectively after UAE. The levels of endometrial integrin β3 were evaluated by immunohistochemistry assay. The MOD (mean optical density) value of positive cells in endometrial epithelium was used as β3 level index. The serum estrogen and progestogen levels were measured for all groups specimens collection. 【Results】The MOD value of endometrial integrin β3 for the control group and UAE group were 0.399±0.038 (control group)

0.268±0.035 (A1 subgroup)

0.321±0.038 (A2 subgroup) and 0.366±0.043 (A3 subgroup)

respectively. The statistical analysis indicated MOD values of β3 levels in control group were significantly higher than those in A1

A2

and A3 subgroup

respectively (P1<0.01

P2<0.01

P3<0.05); and they were significantly higher in A2 subgroup than in A1 subgroup (P<0.01)

also in A3 subgroup than in A2 subgroup (P<0.01). The serum level of estrogen and progestogen between all groups were not statistically significant different (P>0.05). 【Conclusion】The level of integrin β3 in endometrium would decrease after UAE and it might lead to negative influence on endometrial receptivity in some extent. With time prolonged after embolization

the level of β3 might have the trend to recover gradually.