白细胞介素-17及其受体在垂体瘤中的表达及临床意义

您当前的位置：

首页 >

文章列表页 >

白细胞介素-17及其受体在垂体瘤中的表达及临床意义

更新时间：2023-12-12

- 白细胞介素-17及其受体在垂体瘤中的表达及临床意义
- Expression of Interleukin -17 and Its Receptor in Pituitary Adenomas and Its Clinical Significance
- 中山大学学报（医学科学版） 2011年32卷第2期
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R73
- 网络首发：2011-03-20，
  
  纸质出版：2011
- 稿件说明：
移动端阅览
白细胞介素-17及其受体在垂体瘤中的表达及临床意义[J]. 中山大学学报（医学科学版）, 2011,32(2).

Expression of Interleukin -17 and Its Receptor in Pituitary Adenomas and Its Clinical Significance[J]. Journal of Sun Yat-sen University (Medical Sciences), 2011, 32(2).
白细胞介素-17及其受体在垂体瘤中的表达及临床意义[J]. 中山大学学报（医学科学版）, 2011,32(2). DOI：

Expression of Interleukin -17 and Its Receptor in Pituitary Adenomas and Its Clinical Significance[J]. Journal of Sun Yat-sen University (Medical Sciences), 2011, 32(2). DOI：

摘要

【目的】检测人垂体腺瘤组织中白细胞介素(IL-17)及其受体IL-17R的表达，并探讨其在垂体腺瘤侵袭性发病机制中的作用【方法】收集85例人垂体腺瘤组织标本，分成2组：侵袭性垂体腺瘤组45例非侵袭性垂体腺瘤组40例采用免疫组化法检测各标本IL-17IL-17R的表达随机选取其中50例标本(分成2组:侵袭性组25例非侵袭性组25例)，采用RT-PCR法检测IL-17IL-17R的mRNA表达水平分析IL-17IL-17R的表达与垂体腺瘤侵袭性的关系【结果】免疫组化结果显示:IL-17IL-17R在侵袭性垂体腺瘤中的强阳性及总阳性表达率分别38.0%和83.0%49%和86.7%，而非侵袭性垂体腺瘤中的强阳性及总阳性表达率分别20.0%和52.5%20.0%和62.5%IL-17IL-17R在侵袭性垂体腺瘤中的表达率明显高于在非侵袭性垂体腺瘤中的表达率，统计学分析显示有统计学意义(P < 0.05)RT-PCR结果显示：侵袭性垂体腺瘤中的IL-17IL-17R mRNA的表达水平明显高于非侵袭性垂体腺瘤，差异有统计学意义(P < 0.05)【结论】 IL-17IL-17R在侵袭性垂体腺瘤组织中的表达明显升高，可能促进了垂体腺瘤侵袭性的发生

Abstract

【Objective】 The study was designed to investigate the role of IL-17 and IL-17R in the pathogenesis of pituitary adenomas by detecting expression of IL-17 and IL-17R in human pituitary adenomas tissue. 【Methods】 A total of 85 specimens of human pituitary adenoma tissue were recruited in our study and were divided into 2 groups

including 45 cases of invasive pituitary adenomas and 40 cases of non-invasive pituitary adenomas. Immunohistochemistry was used to detect expression of IL-17

IL-17R in human pituitary adenomas tissue.50 patients were randomly selected and were divided into 2 groups

including 25 cases of invasive pituitary adenomas and 25 cases of non-invasive pituitary adenomas. RT-PCR was used to detect expression levels of IL-17 mRNA

IL-17R mRNA in human pituitary adenomas tissue. To analyze the relationship between IL-17

IL-17R expression and invasiveness of pituitary adenomas. 【Results】 The results of immunohistochemistry showed that the expression of strong positive rate and the expression of total positive rate of IL-17

IL-17R in invasive pituitary adenomas were 38% and 83%

49% and 86.7% respectively

but that in non-invasive pituitary adenomas were 20% and 57.5%

20% and 62.5% respectively. IL-17

IL-17R expression in invasive pituitary adenomas were significantly higher than that in non-invasive pituitary adenomas. Statistical analysis has statistical significance(P < 0.05).The results of RT-PCR show the levels of IL-17 mRNA

IL-17R mRNA in invasive pituitary adenomas were significantly higher than that in non-invasive pituitary adenomas. Statistical analysis has statistical significance(P < 0.05). 【Conclusions】 The results of immunohistochemistry and RT-PCR show that the expression of IL-17

IL-17R in invasive pituitary adenomas were significantly higher than that in non-invasive pituitary adenomas. These results indicated that the high expression of IL-17

IL-17R is closely related with invasiveness of pituitary adenoma.

关键词

Keywords

references

浏览量

160

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

苯二氮卓受体的提纯及受体亚基单克隆抗体的制备

肾移植术后侵袭性曲霉菌感染的诊治及文献复习

霍乱毒素对垂体腺瘤的诱导分化潜能及机制的研究进展

狗同种辅助性部分肝移植实验研究

SLE患者雌激素受体与睾酮及泌乳素的相关性研究