【Objective】 To evaluate the population-based prevalence and risk factors of noncardiac chest pain (NCCP) in Guangzhou

China. 【Methods】 In September 2009

a multi-stage sampling survey (face-to-face interview) was carried out in Nonglin Community

Guangzhou

using the Rose Angina Questionnaire and a validated Chinese version of Reflux Disease Questionnaire. Chi-square test or Fisher’s exact test were performed to analyze the categorical variables. Risk factors for NCCP were identified using multiple logistic regression analysis. 【Results】 A total of 1 707 residents (male 814

female 893) were investigated with the response rate of 100%. Mean age of the subjects was 51 (S = 18) years. Chest pain over the past year was present in 92 subjects (5.4%

95%CI 4.3%-6.5%)

while NCCP was present in 61 subjects (3.6%

95%CI 2.7%-4.5%). The prevalence of NCCP was higher in women than in men(4.8% vs 2.2%

χ2 = 8.379

P = 0.004). Among those with NCCP

8.2% had experienced heartburn and/or acid regurgitation

and 47.5% had history of hypertension. By multiple logistic regression analysis with gender and age adjustment

presence of heartburn and/or acid regurgitation(OR=3.8

95% CI 1.1-12.9

P = 0.034)

non-steroidal anti-inflammatory drug (NSAID) usage (OR = 10.5

95%CI 5.1-21.7

P < 0.001)

and hypertension (OR = 2.7

95%CI 1.4-5.2

P = 0.003) were risk factors associated with NCCP. 【Conclusions】 NCCP is common in the general population in Nonglin Community

Guangzhou. Heartburn and/or acid regurgitation

NSAID usage and hypertension may be risk factors associated with NCCP.