miR-143、miR-145在膀胱癌中的表达及意义

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miR-143、miR-145在膀胱癌中的表达及意义

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- miR-143、miR-145在膀胱癌中的表达及意义
- Expression and Significance of miR-143 and miR-145 in Bladder Cancer
- 中山大学学报（医学科学版） 2011年32卷第6期
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  中图分类号： R737.1
- 网络首发：2011-11-20，
  
  纸质出版：2011
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miR-143、miR-145在膀胱癌中的表达及意义[J]. 中山大学学报（医学科学版）, 2011,32(6).

Expression and Significance of miR-143 and miR-145 in Bladder Cancer[J]. Journal of Sun Yat-sen University (Medical Sciences), 2011, 32(6).
miR-143、miR-145在膀胱癌中的表达及意义[J]. 中山大学学报（医学科学版）, 2011,32(6). DOI：

Expression and Significance of miR-143 and miR-145 in Bladder Cancer[J]. Journal of Sun Yat-sen University (Medical Sciences), 2011, 32(6). DOI：

摘要

【目的】探讨膀胱癌中miR-143、miR-145的表达及其与膀胱癌临床病理特征的关系。【方法】采用miRNA表达谱芯片、Northen blot、Real-time PCR法检测miR-143、miR-145在膀胱癌中的表达，分析miR-143、miR-145的表达与膀胱癌临床分期分级的关系。【结果】miRNA表达谱芯片、Northen blot、Real-time PCR法均提示miR-143、miR-145在膀胱癌中较癌旁正常膀胱组织中表达明显降低，差异具有统计学意义。miR-143、miR-145的低表达在不同临床分期与分级的膀胱癌中差异不明显。【结论】miR-143、miR-145在膀胱癌中明显低表达，可能与膀胱癌的发生密切相关。

Abstract

【Objective】To investigate the expression of miR-143 and miR-145 in bladder cancer and their association with clinicopathologic features of bladder cancer. 【Methods】 miRNA microarray

Northen blot

real-time PCR were used to detect the expression of miR-143 and miR-145 in bladder cancer and their association with clinical stages and grades were analyzed. 【Results】The expression of miR-143 and miR-145 were significantly decreased in bladder cancer compared with normal adjacent tissues by miRNA microarray

Northen blot and real-time PCR. However

there were not significant differences in different clinical stages and grades of bladder cancer. 【Conclusion】The expression of miR-143 and miR-145 were significantly decreased in bladder cancer

which may be closely involved in the tumorigenesis of bladder cancer.

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