【Objective】To study the effect of Interferon-γ(IFN-γ)on preventing relapse of condyloma acuminatum (CA).【Method】Seventy-six patients were diag nosed as CA .The patients having connective tissue disease

allergic disease

serious sy stemat ic disease

other virus disease

immuno-modulatory drug o r immunosuppressive drug to be used in one year were excluded .The rash of all pat ients w ere eliminated wi th elect rofulgurat ion .The patients were divided into two g roups :IFN-γand control.Thirty-eight cases of patients wi th CA w ere treated w ith IFN-γand were compared w ith 38 patients t reated w ith Poly I :C .The T-cell subpopulation (CD3 、CD4 、CD8)in peripheral blood of patients treated w ith IFN-γw ere determined by APAAP before elect rofulguration and af ter therapy .All the patients were followed-up fo r 6 months .【Results】The result s showed that the relapse rate was 15.8 %in IFN-γgroup

w hile i t w as 36.8 %in the cont rol in 6 months af ter therapy . In 32 patients

w ho had no relapse in 6 months af ter therapy

the T-cell recovered to normal .While there w as no significant change in 6 patient s wi th relapse in 6 months af ter therapy .【Conclusion】It indicates that the relapse rate of the therapy g roup is signif icantly lower than the control (χ2 =4.34

P <0.05).IFN-γis a cell factor effective to prevent and cure CA .