【Objet ive】To study the expression and sig nificance of CD44v6 and nm23 proteins

and the relationship between the two proteins in carcinomas of gallbladder .【Method】36 cases of carcinomas and 27 cases peripheral epithelium of by carcinoma in gallbladder were detected w ith immunohistochemistry for the expression of CD44v6 and nm23 pro teins .【Result s】The posi tive rates of CD44v6 and nm23 in carcinoma w ere 41.7 %and 72.2 % respectively

showing significantly higher rates than those in the peripheral epithelium of carcinoma(P <0.01).There w as positive relation betw een the expression of CD44v6 and lymphoid node metastasis(P = 0.002)

inverse relation between nm23 and lymphoid node metastasis and clinical stage(P w as 0.003 and 0.03

respectively).There was inverse relation between CD44v6 and nm23 proteins (P =0.034).【Co nclusions 】CD44v6 and nm23 proteins may play an important role in carcinogenesis

lymphoid node metastasis and prog ression of carcinoma in gallbladder .They can be tumor markers to estimate the invasion and lymph node metastasis in carcinomas of gallbladder .