【Objective】To evaluate the development of fetal nervous system by using three- dimensional ultrasound and to compare the difference between normal fetuses and fetuses with growth restriction.【Methods】Fetuses that under⁃ went prenatal ultrasound screening between June 1st 2017 and December 31st 2018 were included. All the cases were divided into two groups according to the estimated weight of the fetus：the normal group and the FGR group（the estimated weight less than 5 percent of the gestational week）. The development of fetal sylvian fissure，parietoocipital sulcus and calcarine sulcus were analyzed according to gestational week. The depth of fetal sylvian fissure ，parietoocipital sulcus and calcarine sulcus were compared between normal fetuses and the fetuses with growth restriction. 【Results】During the study period， 386 normal fetuses and 64 fetuses with growth restriction were included. The median gestational week in normal group was 25+2（22+5~29+1）weeks and the median gestational week in FGR group was 28+2（26+2~30+5）weeks. The depth of fetal sylvian fissure，parietoocipital sulcus and calcarine sulcus had a linear positive correlation with gestational week. The depth of fetal sylvian fissure，parietoocipital sulcus and calcarine sulcus were significantly different between normal fetuses and fetuses with growth restriction.【Conclusions】The depth of fetal sylvian fissure parietoocipital sulcus and calcarine sulcus varies according to gestational week. Fetal brain parenchyma may be mal-developed in FGR fetuses ， so intervention and rehabilitation need to be carried out after birth.