1.河南中医药大学第一附属医院儿科医院,河南 郑州 450046
2.河南中医药大学儿科医学院,河南 郑州 450000
盛道宇,第一作者,研究方向:中医药防治儿童肾脏与风湿免疫性疾病,E-mail:1020338603@qq.com
收稿:2025-09-23,
修回:2025-10-23,
录用:2025-11-05,
纸质出版:2025-11-20
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盛道宇,丁樱.非编码RNA调控细胞程序性死亡影响慢性肾脏病的研究进展[J].中山大学学报(医学科学版),2025,46(06):920-934.
SHENG Daoyu,DING Ying.Advances on the Regulation of Programmed Cell Death by Non-coding RNAs in Chronic Kidney Disease[J].Journal of Sun Yat-sen University(Medical Sciences),2025,46(06):920-934.
盛道宇,丁樱.非编码RNA调控细胞程序性死亡影响慢性肾脏病的研究进展[J].中山大学学报(医学科学版),2025,46(06):920-934. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0602.
SHENG Daoyu,DING Ying.Advances on the Regulation of Programmed Cell Death by Non-coding RNAs in Chronic Kidney Disease[J].Journal of Sun Yat-sen University(Medical Sciences),2025,46(06):920-934. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0602.
慢性肾脏病(CKD)是一种发病率和死亡率较高的常见疾病。越来越多的研究表明,程序性死亡(PCD)在CKD的发生发展中具有重要作用。非编码RNA(ncRNA) 是指不具有编码功能的RNA,已被确定为调控基因表达的关键因子,可影响包含PCD在内的多种生物过程。本文综述了ncRNA参与调控CKD后细胞凋亡、自噬、焦亡、铁死亡、坏死性凋亡和泛凋亡的最新研究进展,探究了不同途径之间的串扰,并从外泌体疗法、中药活性成分、新型药物3方面归纳了ncRNA调控PCD相关的治疗策略,以期为临床提供新的治疗靶点和思路。
Chronic kidney disease (CKD) is a common disease with high morbidity and mortality. Increasing evidence has indicated that programmed cell death (PCD) plays a significant role in the pathogenesis and progression of CKD. Non-coding RNA (ncRNA), defined as a category of RNA that lacks coding potential, has emerged as a pivotal regulator of gene expression. This regulatory function of ncRNA extends to various biological processes, including PCD. This paper reviews the recent advances on the involvement of ncRNAs in the regulation of apoptosis, autophagy, pyroptosis, ferroptosis, necroptosis, and PANoptosis in CKD. It explores the crosstalk between different pathways and categorizes therapeutic strategies targeting ncRNA regulation of PCD into three main areas: the active ingredients of traditional Chinese medicine, tissue engineering technologies, and drugs. The objective of this study is to identify novel therapeutic targets and strategies for clinical treatment.
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