西藏民族大学医学院高原低氧环境与生命健康实验室,陕西 咸阳712082
赵康杓,第一作者,研究方向:肿瘤分子病理学和藏医药抗肿瘤分子机制,E-mail: 2407529084@qq.com
收稿:2025-09-20,
修回:2025-10-02,
录用:2025-11-04,
纸质出版:2025-11-20
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赵康杓,王小平.线粒体自噬和能量代谢在消化道肿瘤中的研究进展[J].中山大学学报(医学科学版),2025,46(06):935-944.
ZHAO Kangshao,WANG Xiaoping.Research Progress on Mitophagy and Energy Metabolism in Digestive Tract Tumors[J].Journal of Sun Yat-sen University(Medical Sciences),2025,46(06):935-944.
赵康杓,王小平.线粒体自噬和能量代谢在消化道肿瘤中的研究进展[J].中山大学学报(医学科学版),2025,46(06):935-944. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0603.
ZHAO Kangshao,WANG Xiaoping.Research Progress on Mitophagy and Energy Metabolism in Digestive Tract Tumors[J].Journal of Sun Yat-sen University(Medical Sciences),2025,46(06):935-944. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0603.
线粒体自噬是一种进化上高度保守的选择性自噬过程,通过特异性识别并清除功能受损或多余的线粒体,以维持细胞内稳态和线粒体质量监控。在肿瘤发生过程中,线粒体自噬可清除受损线粒体,减少活性氧(ROS)积累,从而维持细胞稳态。能量代谢是指细胞通过糖酵解、氧化磷酸化等生化过程将营养物质中的化学能转化为三磷酸腺苷(ATP),为细胞生命活动提供能量的核心生物学过程。目前消化道肿瘤的研究现状不断进展,但目前的瓶颈在于其复杂的代谢适应性与治疗耐药性。靶向线粒体自噬与能量代谢的交互作用成为治疗该疾病的一种新兴策略。对于消化道肿瘤的线粒体自噬与能量代谢研究,包括其双向调控网络的分子机制及其在靶向治疗中的应用等方面尚待系统梳理。因此,本文就线粒体自噬与能量代谢的交互作用在消化道肿瘤中的应用进行综述,旨在为未来相关研究提供参考。
Mitophagy is an evolutionarily highly conserved selective autophagy process that maintains cellular homeostasis and mitochondrial quality control by specifically recognizing and removing damaged or superfluous mitochondria. During tumorigenesis, mitophagy eliminates damaged mitochondria and reduces the accumulation of reactive oxygen species (ROS), thereby helping to sustain cellular homeostasis. Energy metabolism refers to the core biological process through which cells convert chemical energy from nutrients into adenosine triphosphate (ATP) via biochemical pathways such as glycolysis and oxidative phosphorylation, providing energy for cellular activities. While research on gastrointestinal tumors is advancing rapidly, a major bottleneck lies in their complex metabolic adaptations and therapeutic resistance. Targeting the interplay between mitophagy and energy metabolism has emerged as a promising therapeutic strategy for this disease. Current research on mitophagy and energy metabolism in gastrointestinal tumors, including the molecular mechanisms of their bidirectional regulatory network and applications in targeted therapies, remains to be systematically elucidated. Therefore, this review summarizes the implications of the mitophagy-energy metabolism interplay in gastrointestinal tumors, with the aim of providing insights for future research.
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