Transfer Strategy of Obtaining Fewer than 3 Eggs in IVF Cycle

LI Ting-ting; CHEN Pan-yu; WANG Yan-fang; FANG Cong

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Transfer Strategy of Obtaining Fewer than 3 Eggs in IVF Cycle

更新时间：2023-11-01

- Transfer Strategy of Obtaining Fewer than 3 Eggs in IVF Cycle
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 41, Issue 4, Pages: 596-602(2020)
- 作者机构：
  
  中山大学附属第六医院生殖医学研究中心，广东广州 510655
- 作者简介：
  
  FANG Cong; E-mail: fangconggd@163.com
- 基金信息：
- DOI：
  CLC： R711.6
- Published：15 July 2020，
  
  Received：16 February 2020，
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李婷婷,陈攀宇,王艳芳等.体外受精周期获卵不多于三枚胚胎移植策略[J].中山大学学报（医学科学版）,2020,41(04):596-602.

LI Ting-ting,CHEN Pan-yu,WANG Yan-fang,et al.Transfer Strategy of Obtaining Fewer than 3 Eggs in IVF Cycle[J].Journal of Sun Yat-sen University(Medical Sciences),2020,41(04):596-602.
李婷婷,陈攀宇,王艳芳等.体外受精周期获卵不多于三枚胚胎移植策略[J].中山大学学报（医学科学版）,2020,41(04):596-602. DOI：

LI Ting-ting,CHEN Pan-yu,WANG Yan-fang,et al.Transfer Strategy of Obtaining Fewer than 3 Eggs in IVF Cycle[J].Journal of Sun Yat-sen University(Medical Sciences),2020,41(04):596-602. DOI：

摘要

目的

探讨体外受精（IVF）周期获卵≤3枚胚胎移植策略。

方法

回顾性分析2017年1月至2019年4月于中山大学附属第六医院生殖医学研究中心行IVF/ICSI助孕患者共1 600个周期，分为3组：1组：新鲜周期D3移植（615例），2组：复苏周期D3移植（525例），3组：复苏周期囊胚移植（460例），收集3组患者助孕资料，多因素回归分析比较3组间的生化妊娠、临床妊娠及活产情况。

结果

3组患者年龄、基础FSH、AMH无明显差别，

检验结果均

0.05，即两组数据总体一般资料无差异。1组与2组相比，1组有更高的生化妊娠率、临床妊娠率及活产率（38.2%

vs.

29.3%，34.5%

vs.

25.9%，18.2%

vs.

11.2%）

差异有统计学意义。若患者因各种原因取消移植，复苏周期的囊胚移植（3组），生化妊娠率、临床妊娠率及活产率明显高于2组（36.7%

vs.

29.3%，33.4%

vs.

25.9%，13.7%

vs.

11.2%）

差异有统计学意义。通过多因素回归分析，在控制了年龄、AMH、胚胎移植等级等潜在混杂因素后，1组的活产率仍显著高于2组[OR=1.906 (1.272-2.857)，

=0.002]，3组的活产率仍显著高于2组[OR=3.388 (1.876-6.118)，

=0.000]。

结论

IVF周期中，若患者获卵≤3枚，争取新鲜周期D3移植；若取消移植，全胚冷冻建议囊胚冷冻。

Abstract

Objective

To explore the strategy of embryo transfer with ≤3 eggs in IVF cycles.

Methods

A retrospective study was conducted with clinic-based data in the Reproductive Medicine Centre of the Sixth Affiliated Hospital of Sun Yat-sen University from Jan 2017 to Apr 2019. A total of 1 600 cycles were divided into 3 groups: fresh D3 embryo transfer (Group 1，

=615)，frozen D3 embryo transfer (Group 2，

=525)

frozen blastocyst transfer (Group 3，

=460). We compared the general character of patients and clinical outcomes among the 3 groups.

Results

There were no significantly differences found in age， AMH， and basal FSH among the 3 groups．Biochemical pregnancy

clinical pregnancy and live birth rates (38.2%

vs.

29.3%，34.5%

vs.

25.9%，18.2%

vs.

11.2%) were significantly higher in group 1 than those in group 2. These differences were statistically significant. When patients canceled fresh embryo transfer due to various reasons

better biochemical pregnancy

clinical pregnancy and live birth rates were achieved in group 3 than group 2（36.7%

vs.

29.3%，33.4%

vs.

25.9%，13.7%

vs.

11.2%）. These differences were also statistically significant. Through multivariate regression analysis

after controlling for potential confounding factors such as age

AMH and embryo transfer grade

the live birth rate of group 1 was still significantly higher than that of group 2 [OR=1.906(1.272-2.857)

=0.002]

and the live birth rate of group 3 was still significantly higher than that of group 2 [OR = 3.388 (1.876-6.118)

= 0.000].

Conclusions

In patients with no more than 3 oocytes retrieved

fresh D3 embryo transfer achieves optimal pregnancy and live birth rate. If frozen embryo transfer is performed

blastocyst transfer is recommended.

关键词

体外受精-胚胎移植新鲜周期复苏周期妊娠率

Keywords

IVF-ETfresh embryo transferfrozen embryo transferpregnancy rate

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