Journal of Sun Yat-sen University (Medical Sciences)

Journal of Sun Yat-sen University (Medical Sciences) wx-icon
  • 主编：GAO Guoquan
  • ISSN:1672-3554
  • CN:44-1575/R
  • 主管单位：the Ministry of Education of China
  • 主办单位：Sun Yat-sen University
  • 出版周期：Bimonthly
  • 电话：020-87331643

Quick Entry

  • Author Center Author Center
  • Review Center Review Center
  • Office Center Office Center
  • Journal Center Journal Center
  • Latest Articles
  • Online First
  • Archive
更多
Vol. 46 期 1，2025 2025年46卷第1期

  • Invited Review

    ZHANG Jie, YANG Zhengfei

    DOI：10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0101
    摘要：Ischemia reperfusion injury （IRI） is often accompanied by serious clinical manifestations， including myocardial hibernation， acute heart failure， brain dysfunction， kidney dysfunction， gastrointestinal dysfunction， liver transplant rejection， systemic inflammatory response syndrome， multiple organ dysfunction syndrome， and so on， which pose important treatment challenges for doctors in clinical practice. Single cell sequencing technology is high-throughput sequencing of the genome， transcriptome， or epigenome at the single-cell level， in order to reveal cellular heterogeneity， and to understand the developmental trajectory， type， state， and various interactions of cells. Since its first discovery， single-cell sequencing technology has been widely applied in various fields， especially in early diagnosis and personalized treatment of tumors. This article mainly reviews the application and progress of single-cell sequencing in various organ dysfunction caused by IRI， so as to further understand the mechanism and signaling pathways of IRI， and to provide new ideas for targeted therapy of organ IRI.  
    关键词：ischemia reperfusion injury;single cell sequencing;apoptosis;transplantation;heterogeneity;signal pathway   
    0
    |
    0
    |
    0
    <HTML>
    <L-PDF><Meta-XML>
    <引用本文> <批量引用> 80894334 false
    更新时间：2025-01-20

  • ZHANG Xinping

    DOI：10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0102
    摘要：In the process of accelerating the construction of a strong country in health and sports in China， the mode of promoting health has shifted from passive health to active health. Guided by the concept of "active health"， there is a new understanding of the relationship between sports， health， and medical care. The integration of sports and medicine is a concrete manifestation and implementation of the concept of "active health"， and an important measure to implement the Healthy China strategy， which is regarded as an important strategy to promote public health reform. This article reviews the historical path of the integration of sports and medicine from its concept to practical implementation， and finds that China proposed the integration of sports and medicine relatively late， but it has become a research hot spot； The sports and medical departments have launched guidelines for chronic disease exercise and standards related to exercise prescriptions， and local governments in China have explored diversified models of integrating sports and medicine； Under the institutional requirements of top-level design， the exploration of the "integration of sports and medicine" model is flourishing. There are currently problems in promoting the integration of sports and medicine， such as the lack of a "sports and medicine integration" system and a shortage of "sports and medicine integration" talents. Drawing on the international experience of integrating sports and medical services in other countries， propose a development strategy of "concept first， government led， and sports and medical cooperation"； Propose institutional optimization suggestions such as improving medical insurance related systems， establishing certification， employment， and management systems for integrated sports and medical talents， and improving the training system for integrated sports and medical talents in universities； And propose a "dual wheel" promotion path of upgrading hospital rehabilitation centers and expanding community health centers， in order to provide reference for policy formulation and promote the integration of sports and medicine to play a greater role in China's public health field.  
    关键词：healthy china;proactive health;passive health;integration of sports and medicine;research progress   
    2
    |
    1
    |
    0
    <HTML>
    <L-PDF><Meta-XML>
    <引用本文> <批量引用> 80894682 false
    更新时间：2025-01-20

  • Review

    WANG Xiaojun, LIU Junxiu

    DOI：10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0103
    摘要：Gynecological malignancies pose a serious threat to women's health， and the early diagnosis and precise treatment are crucial for improving patients' prognosis. With the rapid advancement of Artificial Intelligence （AI） technology， it has become a revolutionary tool in the medical field. Through functions such as image recognition， data mining， and pattern recognition， it has opened up new avenues for the diagnosis and management of gynecological malignancies. This review comprehensively summarizes the latest research progress of AI in cervical cancer， ovarian cancer and endometrial cancer， with a special focus on its practical applications in early screening， diagnosis， treatment effect evaluation and prognosis prediction of tumors， so as to provide guidance for the future research direction of AI in gynecological malignancies.  
    关键词：artificial intelligence;cervical cancer;ovarian cancer;endometrial cancer;early diagnosis;prognosis prediction   
    3
    |
    6
    |
    0
    <HTML>
    <L-PDF><Meta-XML>
    <引用本文> <批量引用> 80894565 false
    更新时间：2025-01-20

  • WANG Bin, FENG Yi

    DOI：10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0104
    摘要：Human exhaled gas is rich in volatile organic compounds （VOCs）， which can reach thousands of types. In addition to VOCs carried into the body by the outside air， the vast majority of VOCs come from human metabolism and the metabolism of microorganisms in the human body. Therefore， exhaled VOCs carry a large amount of information inside the human body， which is similar to the "fingerprint" of exhaled substances of an individual's metabolic status， thus making it an ideal tool for health monitoring and disease diagnosis. In recent years， a large number of studies on disease and exhaled VOCs have shown valuable results. Many diseases in the human body are closely related to oxidative stress reaction in the body， and oxidative stress reaction will also produce a large number of VOCs discharged through the lungs， which has become a new window for monitoring diseases. In the future， the use of exhaled VOCs analysis to detect and diagnose infectious diseases， metabolic diseases and tumors may become a new trend. This paper will review the concept， collection， detection， clinical application and the relationship between VOCs and diseases in exhaled breath.  
    关键词：exhaled volatile organic compounds;tumor;asthma;chronic obstructive pulmonary disease;infection   
    2
    |
    6
    |
    0
    <HTML>
    <L-PDF><Meta-XML>
    <引用本文> <批量引用> 80894378 false
    更新时间：2025-01-20
查看更多
0