【Objective】To investigate the effect of dexmedetomidine on the phagocytosis of macrophages.【Methods】 RAW264.7 cells were divided into control group，DEX group，and BRL44408 + DEX group. Expression of α2A  adrenergic receptor，p-Akt and Akt were detected by Western Blotting；Phagocytosis Assay Kit（IgG PE）was used to measure the phagocytosis of macrophages. 【Results】 α2A   adrenergic receptor was detected in RAW264.7  cells；Dexmedetomidine could enhance the phagocytosis of macrophages（ < 0.001），and BRL44408 reversed the enhancement of phagocytic ability of macrophages（< 0.001）；Dexmedetomidine upregulated the expression of Akt in RAW264.7  cells，while the use of BRL44408 inhibited the activation of the Akt pathway（< 0.01）.【Conclusion】Dexmedetomidine could enhance phagocytosis of RAW264.7 by activating the Akt pathway through the α2A  adrenergic receptor.