【Objective】To evaluate the microcirculation changes in retina and choroid of central serous chorioretinopathy（CSC）by using optical coherence tomography angiography（OCTA）.【Methods】A retrospective study was performed in 67 eyes of 61 patients with CSC diagnosed by conventional eye examination，fundus fluorescein angiography（FFA）and indocyanine green angiography（ICGA），30 eyes of 15 age matched healthy people were selected as normal control group. OCTA was performed to study the microcirculation within the chorioretinal layers.【Results】The vessel density of superficial retina（VDSR）and deep retina（VDDR）layers in CSC eyes were lower than that in normal eyes，but the difference was no statistical significance（P = 0.325，P = 0.056）. The vessel density of superficial choroid （VDSC）layer in CSC eyes was significantly lower than control group. In subgroup analysis，the value of VDSR，VDDR in chronic group were lower than that of the control group，and the difference was statistically significant（P = 0.042，P =0.037）；While there was no statistical differences in VDSR，VDDR between acute group and control group.【Conclusion】 Our study found that the abnormal microcirculation in CSC was existed. The VDSC in CSC was decreased. Furthermore， to our knowledge，the VDSR and VDDR were firstly observed to be attenuated in chronic CSC. This indicated that the microcirculation abnormality may involve the retina as well as superficial choroid in case with longer course of disease.