【Objective】To investigate the molecular mechanism of miR-192/-215 targeting BIVM in human gastric cancer.【Methods】First，BIVM was the target gene of miR-192/-215 screened by the target gene prediction in solico and gene microarrays. Real-time quantitative PCR verified the results of the microarrays. Then the double-luciferase reporter plasmids were constructed to test that BIVM was the target gene of miR-192/-215. Subsequently，BIVM-siRNA was transfected，to know the effects of BIVM-siRNA on proliferation and apoptosis of gastric cancer cells. 8 nude mice were randomly divided into two groups：BIVM-siRNA experimental group and NSC-siRNA control group. Gastric cancer cells transfected with BIVM-SiRNA were implanted under the skin of nude mice to observe the effect of BIVM on the tumorige? nicity of gastric cancer cells.【Results】BIVM was screened as miR-192/-215 target gene by gene microarrays and quanti? tative PCR. Double-luciferase reporting assays were performed to identify the BIVM as miR-192/-215 target gene. The cell proliferation assays showed that BIVM promoted the proliferation of gastric cancer cells（P<0.05）. Test of flow cytome?try showed that BIVM inhibited the apoptosis of gastric cancer cells（P<0.05）. Mouse tumorigenesis test confirmed that BIVM could promote gastric cancer cells growth in vivo（P<0.05）.【Conclusion】BIVM plays a role in the carcinogenesis of gastric cancer，and miR-192/-215 targeting BIVM promotes the development of gastric cancer.