【Objective】To analyze the expression profile variation of circle RNA（circRNA）in tongue squamous cell carcinoma（TSCC）tissue and para-carcinoma tissue.【Methods】CircRNA microarray technology was performed to in? spect the difference of circRNA expression in 4 cases of TSCC tissues and 4 cases of para-carcinoma tissues，and then make analysis after the quality control and homogenization of raw data，to identify which have more than 2 times variation and significant difference（P<0.05）by statistical analysis as circRNA with differential expression. To perform functional analysis on circRNA with differential expression.【Results】Compared with para-carcinoma tissue，there were 17171 circRNA differentially expressed in TSCC tissue，while 9982 increase more than 2 times and 7189 reduce more than 2 times.【Conclusion】circRNA expression profile in TSCC changes significantly comparing with the para-carcinoma tis? sue，some differentially expressed circRNA may regulate the occurrence and progression of TSCC through a competitive combination of miRNA.