： 【Objective】To determine the efficacy and safety of 1064nm Q-switched laser combined with drug therapy in the treatment of mild to moderate rosacea.【Methods】73 patients with mild to moderate rosacea were divided into two groups randomly. The treatment group including 37 patients were treated with Q-switched laser combined with drug thera? py，the control group including 36 patients were treated with drug therapy only. Efficacies and safety were evaluated 6 and 9 weeks after the treatments.【Results】A mean reduction in lesion count was observed，statistically significance differenc? es in effectiveness were found among each group（P<0.05），the effective ratio was 83.8% in treated group，of which was 61.1% in control group，it showed significant difference between these two groups（P<0.05）. There was no side effect. 【Conclusion】1 064 nm Q-switched laser combined with drug therapy has a marked effect on mild to moderate rosacea，it is safe and effective，better than simple drug treatment.