【Objective】To investigate the role of exenatide on angiogenesis in endometrial cancer Ishikawa xenografts in nude mice.【Method】We used the subcutaneous human endometrial cancer cell Ishikawa xenografts in nude mice model，and divided them into control group and exenatide-treated group. The harvested tumors were preserved for immunohistochemistry staining and western blot analysis.【Results】The micro-vessel density（CD31 positive）in exenatide-treated group was（13.2 ± 1.4）/400 power field，less than that in control group［（25.9 ± 5.8）/400 power field ］（P < 0.01）. The expression level of VEGF was significantly lower in exenatide-treated group than that in control group（P < 0.05）. The mean density of tumor associated macrophages（F4/80 positive）is（31.4 ± 3.4）% in exenatide -treated group and（72.1 ± 4.2）% in control group with significant difference（P < 0.01）. 【Conclusion】Exenatide weaks tumor angiogenesis within endometrial cancer Ishikawa xenografts in nude mice.