【Objective】To evaluate the value of cardiac screening in the first trimester by using three-dimensional ultrasound with spatiotemporal image correlation（STIC）and to analyze the value of different views for cardiac assessment.【Methods】This study retrospectively reviewed the eighty-seven fetuses with congenital heart diseases which were diagnosed in our institution between Janu? ary 4th 2013 and June 30th 2016. We compared the detection rate of prenatal ultrasound screening with STIC in the first trimester and the results of postnatal echocardiography or autopsy. In addition，the detection rates of the different planes，including four-chamber view（4CV），outlet of the left ventricle（OLV），outlet of the right ventricle（ORV）and three vessels-trachea view（3VT）were ana? lyzed.【Results】Severe cardiac anomalies were identified in 62 fetuses（71.3%）and non-severe cardiac anomalies were identified in 25 fetuses（28.7%）. Seventy-eight cases（89.7%，78/87）with congenital heart diseases could be detected by using three-dimension? al ultrasound with STIC.The detection ratesfor 4CV，4CV+OLV，4CV+ORV，4CV+3VT，4CV+OLV+ORV and 4CV+OLV+ORV+ 3VT were 48.3%，64.4%，66.7%，79.3%，69.0% and 89.7% respectively.【Conclusions】Three-dimensional ultrasound with STIC could detect congenital heart disease in the first trimester. The four-chamber view plus outlet of the left ventricle，outlet of the right ventricle and three vessels-trachea view could increase the detection rates of congenital heart diseases.