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二步胚胎移植在反复种植失败中的临床应用价值[J]. 中山大学学报(医学科学版), 2016,37(1).
Analysis of Clinical Effectiveness of Two -step Embryo Transfer on Patients with Repeated IVF -ET Failure[J]. Journal of Sun Yat-sen University (Medical Sciences), 2016, 37(1).
摘 要: 【目的】 探究二步胚胎移植在反复种植失败中的临床应用价值。【方法】 回顾性分析2013年7月至2015年7月因既往体外受精-胚胎移植(IVF-ET)失败至本生殖中心再次IVF的患者资料,进行二步胚胎移植的有359例(二步移植组),单纯移植第3天胚胎的362例(D3移植组),单纯移植第5天胚胎的101例(D5移植组)。其中,二步胚胎移植和单纯移植第3天胚胎中各有110个和130个周期患者既往有3个或3个以上IVF失败周期。【结果】①对于既往有IVF失败的患者,二步移植组的胚胎种植率、临床妊娠率与D3移植组、D5移植组相近(20.5% vs 23.2% vs 28.2%、47.1% vs 49.7% vs 44.6%,P > 0.05)。②对于反复种植失败患者,二步移植组的胚胎种植率和D3移植组相近(19.2% VS 19.4%,P>0.05),而临床妊娠率稍高于D3移植组,但差异无统计学意义(44.5% vs 38.5%,P > 0.05)。【结论】 对于反复种植失败患者,二步胚胎移植有可能提高IVF的胚胎种植率和临床妊娠率。
Abstract: 【Objective】 To evaluate the effect of two -step embryo transfer in the patients with repeated IVF -ET failure. 【Methods】A retrospective study was performed in the patients with a history of IVF -ET failure in our reproductive centrefrom July 2013 to July 2015,of which 359 women underwent two -step embryo transfer(two -step group),362 women underwent day -3 embryo transfer only(D3 transfer group),and 101 women underwent day -5 embryo transfer only(D5 transfer group).Among them,there were 110 and 130 women had at least 3 IVF -ET failed cycles in two -step group and D3 transfer group respectively. 【Results】 1. For the patients had IVF -ET failed cycles,the implantation and pregnancy rate were similar in three groups(two -step group vs D3 transfer group vs D5 transfer group, 20.5% vs 23.2% vs 28.2%, 47.1% vs 49.7% vs 44.6%,P > 0.05,respectively). 2. For the patients with repeated IVF -ET failure,the implantation rate was similar in two -step group and D3 transfer group.(19.2% vs 19.4%,P> 0.05).The clinical pregnancy rate in two -step group was higher than D3 transfer group,but there was no statistical significance(44.5% vs 38.5%,P > 0.05).【Conclusion】 For the patients with repeated IVF -ET failure,two -step embryo transfer may improve IVF implantation and pregnancy rate.
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