【Objective】 The aim of this study was to explore the relationship between CA19-9 and clinicopathological characteristics in endometrial cancer. 【Methods】 2342 patients source from cooperative?hospitals for endometrial cancer prevention and control project with surgically treated endometrial carcinoma preoperatively evaluated with serum levels of CA19-9 were included in this retrospective study. 【Results】 The serum CA19-9 positive rates in endometrial cancer increased with stages which were 17.4%

32.9%

39.5% and 44.3% for stage Ⅰ

Ⅱ

Ⅲ

and Ⅳ

respectively (P 0.05)

but related with tumor grade

deep myometrial invasion

abdominal dropsy cytology

cervical stroma involvement

lymph-vascular space invasion

adnexal metastasis and lymph node metastasis (P < 0.05). Multivariate analysis revealed that poorly differentiated

deep myometrial infiltration

cervical involvement and advanced cancer related with positive serum CA19-9 (P < 0.05). 【Conclusions】 preoperative serum CA19-9 level was a valuable index in prediction pathological high risk factors of endometrial cancer.