网络首发:2013-11-20,
纸质出版:2013
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肠易激综合征患者静息状态下大脑右侧海马的功能连接[J]. 中山大学学报(医学科学版), 2013,34(6).
Functional Connectivity of Right Hippocampus in Irritable Bowel Syndrome duringResting State[J]. Journal of Sun Yat-sen University (Medical Sciences), 2013, 34(6).
【目的】 利用功能磁共振成像技术(fMRI),探索肠易激综合征患者(IBS)静息状态下大脑右侧海马的功能连接与正常对照组的区别,了解大脑右侧海马及其功能相关区域在IBS患者的病理机制中的作用。【方法】对21例IBS患者及21例年龄、性别、受教育程度均匹配的健康对照组进行静息状态下的功能磁共振成像扫描,选取大脑右侧海马为种子点,比较两组之间大脑右侧海马功能连接的差别。【结果】与正常对照组相比,IBS患者在静息状态下大脑右侧海马与右侧扣带回中部、右侧岛叶、左右侧的中央前回的功能连接降低;与左侧额中回、左侧顶上回以及左侧楔前叶的功能连接增强。【结论】 本研究证明静息状态下IBS患者大脑右侧海马功能连接存在异常。本研究从功能整合的角度探究IBS患者大脑神经活动的改变,促进我们进一步理解IBS的神经活动特点。
【Objective】 The aim of this study was to understand the role of hippocampusand hippocampus-related regions in the pathological mechanismof irritable bowel syndrome (IBS), we explore the difference of the right hippocampusfunctional connectivity between the irritable bowel syndrome (IBS) and the normalcontrol group in resting state using functional magnetic resonance imaging (fMRI).【Methods】 The resting state fMRI were performed in 21 IBS patients and 21 age, education,and sex-matched normal healthy subjects. The right hippocampuswas selected as the seed and the functional connectivity of the right hippocampuswere compared between the IBS and normal control groups. 【Results】 Compared to thecontrol group, the IBS group showed significantly deceased functional connectivitybetween the right hippocampus and some brain regions, including the right mediancingulum, right insular and bilateral precentral gyrus; the significantly increasedconnectivity with the right hippocampus included the left middle frontal gyrus,the left superior parietal gyrus and the left preceneus. 【Conclusions】 The resultsindicated that the right hippocampus functional connectivity in the IBS group wasabnormal in the resting state. This study investigates the change of the brain neuralactivity in the IBS group from the perspective of functional integration and promotesus to understand the neurobiological characteristic of IBS.
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