【Objective】 To investigate the relationship between the detection rate of prostate cancer (Pca) with prostate specific antigen density (PSAD) and prostate volume (PV) in prostate biopsy. 【Methods】 The data of 262 patients who received transrectal ultrasound (TRUS) guided prostate biopsy in our hospital from July 2008 to May 2011 were prospectively collected and analyzed. The measurement of PSA

DRE

TRUS

and PSAD were performed in all patients before TRUS guided prostate biopsy. 【Results】 There were 101 patients who were diagnosed as Pca among 262 patients with the detection rate of 38.55%. The detection rates of Pca were 53.33% and 72.73% in the patients with PV < 20 mL group and PV ranging from 20 to 30 mL respectively

which had a significantly difference to the detection rates of 23.53% and 25.42% in the patients with PV ranging from 30 to 50 mL group and PV > 50 mL group

respectively. On the other hand

with the threshold of 0.15 ng/mL2 in PSAD

the sensitivity and specificity of detection rate are 47% and 90% respectively. 【Conclusion】 The detection rate of Pca is lower with the increase of the PV. To increase the detection rate of Pca

more cores of biopsy are necessary for larger prostate.