【Objective】 To select effectiveness of microRNAs and correlated with early recurrence after radical surgery in liver cancer by microRNA profiling

which analyzing verified the results by tissue samples on the basis. 【Methods】 10 HCC cases with radical surgery were divided into 2 group: early recurrence group and non-early recurrence group

according to postoperative recurrence in primary hepatocellular carcinoma. MicroRNA profiling study were performed to obtain some different and significant microRNAs. According to literature

mir-144 and mir-502-3p were used to detect HCC recurrence by real-time PCR with 82 HCC cases

and target genes were predicted using bioinformatics. 【Results】 Expression of 7 miRNAs were different and significant in the HCC with early recurrence group. Comparing with non-early recurrrence group

4 miRNAs were up-regulated in early recurrence group. However

3 miRNAs were down-regulated. The result of mir-144 and mir-502-3p expression by real-time PCR was uniformity to microarray. Rb1 might be a potential target gene of mir-144; SET might be a potential target gene of mir-502-3p. 【Conclusions】 Mir-144

mir-451

mir-486-5p

mir-602

mir-551b

mir-96

and mir-502-3p were correlated with early recurrence after radical surgery in primary hepatocellular carcinoma with analyzing and screening of microRNA profile by microarray.