【Objective】 To explore the gene polymorphisms distribution of methylenetetrahydrofolate reductase (MTHFR) C677T

A1298C and methionine synthase reductase (MTRR) A66G among the Han female in Huizhou

Guangdong. 【Methods】 A cross-sectional study was used. A total of 359 oral epithelial cells samples from recruited Han women in Huizhou were collected. The detections of MTHFR and MTRR gene polymorphisms were conducted with Taqman-MGB technology. The distribution of gene polymorphisms was analyzed and compared with partial regions of China

which are Weifang

Zhengzhou

Deyang City and Hainan Province. 【Results】 The frequencies of MTHFR C677T CC

CT and TT genotypes among the Han women in Huizhou were 51.8%

37.3%

and 10.9%. The frequencies of the MTHFR A1298C AA

AC and CC genotypes in Huizhou Han women were 61.6%

31.2%

and 7.2% and the frequencies of the MTRR A66G AA

AG and GG genotypes were 54.6%

39.8%

and 5.6%. Compared with partial regions

the study found that the genotype of MTHFR C677T among the Han women in Huizhou showed statistical difference from that in Weifang

Zhengzhou

and Deyang (P < 0.05). The genotype of MTHFR A1298C in Huizhou Han women showed statistical difference from that in Weifang and Zhengzhou (P < 0.01). The genotype of MTRR A66G in Huizhou Han women showed statistical difference from that in Hainan (P < 0.05) while no difference was found when compared with other regions(P > 0.05). 【Conclusions】 The gene polymorphisms distribution of MTHFR C677T

A1298C and MTRR A66G among the Han women in Huizhou were found to be statistically different from partial regions of China.