【Objective】 To explore the relationship between visfatin levels in serum

follicular fluid and its relationship with PCOS. 【Methods】 Samples from PCOS group (n = 20) and control group (n = 20) were collected. All subjects were women of reproductive age. Sex hormone

glycometabolic indexes were detected in early follicular period. Height

weight

waist circumference

and hip circumference were collected to calculate BMI (body mass index) and WHR (waist to hip ratio). Serum and follicular fluid were preserved to detect visfatin levels. 【Results】 (1) S visfatin levels

FF visfatin levels in PCOS group were higher than that in the control group

respectively (P﹤0.001). (2) In the two groups

S visfatin levels positively correlated with FF visfatin levels (r = 0.67

P﹤0.05; r = 0.87

P﹤0.05). (3) In multiple regression analysis

S visfatin levels can be explained by HOMAIR

WHR

and LH/FSH to some extent by 80%; FF visfatin levels can be explained by S visfatin levels to some extent by 85%. 【Conclusion】 Hypervisfatinemia was evident in the women with PCOS. S visfatin levels and FF visfatin levels in PCOS group elevated

and they correlated positively. FF visfatin may be affected mainly by S visfatin. Visfatin may participate in the pathogenesis of PCOS.