【Objective】 To investigate the effects of EBV LMP2A on biological characters of gastric cancer cells.【Methods】 Human gastric cancer cell line SGC7901 was transfected with a retroviral vector containing the LMP2A gene. The expression of LMP2A gene mRNA was detected by QRT-PCR. The cell proliferation was detected by CCK8 assay. Cell apoptosis were analyzed by flow cytometry. The migration of cell was measured with wound healing assay and Transwell test. Cell tumorigenicity was measured with colony formation assay.【Results】 The LMP2A gene-transfected gastric cancer cells grew vigorously and rapidly
had less apoptotic cells
formed more colonies and up-regulated the ability of migration. 【Conclusion】 The LMP2A gene can significantly enhance the malignancy of gastric cancer cells.