【Objective】The purpose of this study was to determine the changes and significance of hepatoma-derived growth factor (HDGF) and vascular endothelial growth factor (VEGF) in serum and lung tissue from patients with lung cancer. 【Methods】Fifty-six new inpatients diagnosed with lung cancer were enrolled as the study group

fourteen patients with benign pulmonary diseases and fourteen healthy volunteers were selected for control groups. The levels of HDGF and VEGF in serum of all subjects were detected by ELISA

and the HDGF and VEGF expression in lung cancer tissues and adjacent normal lung tissues were detected by immunohistochemical assay.【Results】 Patients with squamous cell lung cancer had higher HDGF levels in their serum than those patients with adenocarcinoma did (P<0.01). Patients with undifferentiated and poorly differentiated lung cancer had higher HDGF levels in serum than those patients with mediate and well differentiated lung cancer did (P<0.01).Patients with NSCLC in stages II-IV had higher levels of HDGF and VEGF in serum than patients with stage I disease did (P<0.05). Lung cancer patients with lymph node metastasis had higher VEGF levels in serum than patients without lymph node metastasis did (P<0.05). There was a positive correlation between VEGF and HDGF levels in serum from the patients with lung cancer (r=0.35

P<0.01). Both HDGF and VEGF expression were dramatically increased in lung tumor tissues compared with adjacent normal lung tissues (P<0.01

P<0.05).There was a positive correlation between the VEGF and HDGF levels in primary lung tumor tissues (r=0.75

P<0.05). 【Conclusions】HDGF and VEGF play an important role in tumor growth and metastasis and there is a relationship between the two factors.