肝移植急性肺损伤患者围手术期血浆Eotaxin 和MCP-2 变化及意义

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肝移植急性肺损伤患者围手术期血浆Eotaxin 和MCP-2 变化及意义

更新时间：2023-12-12

- 肝移植急性肺损伤患者围手术期血浆Eotaxin 和MCP-2 变化及意义
- Change and Significance of Perioperative Blood Eotaxin and MCP-2 of Patients with Acute Lung Injury during Liver Transplantation
- 中山大学学报（医学科学版） 2011年32卷第5期
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  中图分类号： R657.3
- 网络首发：2011-09-20，
  
  纸质出版：2011
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肝移植急性肺损伤患者围手术期血浆Eotaxin 和MCP-2 变化及意义[J]. 中山大学学报（医学科学版）, 2011,32(5).

Change and Significance of Perioperative Blood Eotaxin and MCP-2 of Patients with Acute Lung Injury during Liver Transplantation[J]. Journal of Sun Yat-sen University (Medical Sciences), 2011, 32(5).
肝移植急性肺损伤患者围手术期血浆Eotaxin 和MCP-2 变化及意义[J]. 中山大学学报（医学科学版）, 2011,32(5). DOI：

Change and Significance of Perioperative Blood Eotaxin and MCP-2 of Patients with Acute Lung Injury during Liver Transplantation[J]. Journal of Sun Yat-sen University (Medical Sciences), 2011, 32(5). DOI：

摘要

【目的】观察肝移植急性肺损伤患者围手术期血浆Eotaxin和MCP-2变化并探讨其意义【方法】 66例接受肝移植手术患者

观察其肺损伤发生率;用ELISA方法检测嗜酸性细胞选择性趋化因子(Eotaxin)单核细胞趋化蛋白2(MCP-2)肿瘤坏死因子α(TNF-α)的血浆水平【结果】 ①66例患者有17例发生急性肺损伤(ALI)

发生率为25.8%;术后5例患者死亡

肺损伤患者中死亡率为29.4%②肝移植患者血浆EotaxinMCP-2TNF-α水平在新肝3 h和术后24 h时高于术前

术后24 h最高在各时间点

ALI组血浆Eotaxin MCP-2TNF-α水平明显高于非ALI组 (P < 0.01)【结论】肝移植手术打击使血浆TNF-αEotaxinMCP-2水平增高

急性肺损伤更显著

Eotaxin和MCP-2可能参与急性肺损伤过程

Abstract

【Objective】 To investigate the change and significance of perioperative blood Eotaxin and MCP-2 of patients with acute lung injury during liver transplantation. 【Methods】 The incidence of lung injury of 66 patients scheduled for liver transplantation was observed. The level of blood Eotaxin

MCP-2

and TNF-α was detected by ELISA. 【Results】 (1) Seventeen of 66 patients suffered from ALI

with a incidence rate of 25.8%; and 5 patients died after surgery

among which there was a mortality of 29.4% for ALI patients. (2) Compared with preoperation

blood Eotaxin

MCP-2

and TNF-α showed elevated level at 3 h of neohepatic phase and 24 h after surgery

which was also the highest level during the whole investigation. 【Conclusions】 The level of blood Eotaxin

MCP-2

and TNF-α increased due to the impact of liver transplantation

which aggravated lung injury

and Eotaxin

MCP-2 possibly played an important role during the procedure of acute lung injury.

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