【Objective】 To investigate the expression levels of IL-17 and IL-23 in the serum of patients with allergic rhinitis and the correlation of levels of serum specific IgE

IL-17

and IL-23. 【Methods】 The samples were divided into two groups: the allergic rhinitis group (24 cases) and the normal control group (12 cases). The serum samples were obtained. The levels of serum specific IgE (sIgE) were detected by UniCAP system. The levels of IL -17 and IL-23 in serum were measured by enzyme-linked immunosorbent assay ( ELISA). 【Results】 The levels of serum sIgE were 0 grade in the normal control and were 2 to 6 grades in the allergic rhinitis. The levels of IL-17 and IL-23 in serum were (165 ± 39) pg/ mL and (79 ± 26) pg/ mL in patients with allergic rhinitis

and were (68 ± 18) pg/ mL and (14 ± 4) pg/ mL in the normal controls . The levels of IL-17 and IL-23 were significantly elevated in the allergic rhinitis group as compared with the normal control group (P < 0.05). In the allergic rhinitis group

correlation analysis showed that the level of IL-17 was significantly positively correlated with the level of IL-23 and serum sIgE (r = 0.533 and 0.687

both P < 0.01) and the level of IL-23 was significantly positively correlated with the level of serum sIgE (r = 0.513

P < 0.05).【Conclusion】 IL-17 and IL-23 may play an important role in the pathogenesis of allergic rhinitis.