Abstract：【Objective】To evaluate the reliability and validity of Chinese version of the Pediatric Quality of Life Inventory PedsQL multidimensional fatigue scale among short stature.【Methods】The Cross-sectional surveys was made using this Chinese scale. A total of 570 children and adolescents and their parents were investigated. 522 valid questionnaires were collected，of which 138 were short stature and 384 with normal height，Analysis feasibility，reliability and validity of this Chinese version scale. 【Results】Cronbach alpha coefficients of the parent-proxy report was 0.89，the dimensions ranged from 0.75 to 0.87，Cronbach alpha coefficients of the child self-report was 0.86，the dimensions ranged from 0.70 to 0.80；Test retest reliability was satisfied for intraclass correlation coefficient（ICC）exceeded 0.9 in all dimensions. Correlation coefficients between items and their belong dimensions higher than those with other dimensions；The result of confirmatory factor analysis indicated the main indexes χ2/df = 2.62，CFI = 0.93，TLI = 0.92，NFI = 0.89，RFI = 0.87，IFI = 0.93，RMSEA = 0.056 of self-report and χ2/df = 3.12，CFI = 0.94，TLI = 0.92， NFI = 0.91，RFI = 0.89，IFI = 0.94，RMSEA = 0.064 of proxy-report all met the criteria of psychometrics.【Conclusion】The Chinese version of PedsQL Multidimensional Fatigue Scale has good feasibility，reliability and validity，and can be used to evaluate the fatigue of short stature in children and adolescents in Chinese cultural background.