【Objective】 To investigate the pregnant outcomes of women with polycystic ovary syndrome (PCOS) and the effects of different conceived ways on it. 【Methods】 A total of 220 pregnant women with PCOS in Sun Yat-sen Memorial Hospital (SYSM) of Sun Yat-sen University between January 2007 and December 2010 were collected

11778 pregnant women without PCOS at the same period as the control. The pregnant complication

pregnant outcome

as well as the various conceived ways including natural conception

ovulation and in vitro fertilization-embryo transfer (IVF-ET) were compared. 【Results】 The incidences of spontaneous abortion

abnormal glucose metabolism

hypertensive disorders in pregnancy

premature delivery

twins

fetal growth restriction (FGR) and neonatal jaundice were higher in PCOS group than that in control group (P < 0.05)

which were 34.54% vs 8.86%

49.31% vs 8.22%

10.42% vs 2.17%

18.75% vs 10.13%

22.92% vs 4.26%

7.64% vs 2.11% and 17.36% vs 8.95%

respectively. Besides

the incidence of macrosomia (4.17% vs 2.46%)

fetal malformation (2.08% vs 2.52%)

and neonatal asphyxia (10.42% vs 7.84%) in PCOS group were also increased

compared to the control group

although there were no statistically significance. In terms of the effects of conceived ways on pregnant outcomes

compared to the PCOS patients in natural conception

the incidence of having twins (45.24% vs 2.90%) and FGR (11.90% % vs 1.45%) of PCOS patients conceived by IVF-ET increased; those in patients taking ovulation showed the same trend

whose incidences of twins and FGR were 36.36% and 15.15%

respectively. The preterm birth rate of IVF- ET

ovulation group and natural conception group were 26.19%

27.27%

and 10.14%

respectively. The difference was statistically significant among these three groups. No significant differences were showed on the incidences of the other complications. 【Conclusions】 Incidences of pregnant outcomes including spontaneous abortion

abnormal glucose metabolism

hypertensive disorders in pregnancy

preterm labor

twins

fetal growth restriction and neonatal jaundice

but not macrosomia

fetal malformation and asphyxia

significantly increased among women with PCOS. The conceived ways of PCOS patients play a role on the incidence of twins

FGR

and preterm delivery.