SHAO Li,CHEN Ji-jun,BAO Kai,et al.Influencing Factors of HIV/ AIDS Death Based on Bayesian Cox Proportional Hazard Regression Model[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(02):224-231.
SHAO Li,CHEN Ji-jun,BAO Kai,et al.Influencing Factors of HIV/ AIDS Death Based on Bayesian Cox Proportional Hazard Regression Model[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(02):224-231. DOI: 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0206.
Influencing Factors of HIV/ AIDS Death Based on Bayesian Cox Proportional Hazard Regression Model
To understand the composition of related characteristics of HIV/AIDS cases in Lanzhou and analyze the influencing factors of AIDS-related deaths.
Methods
2
The information of HIV/AIDS cases reported in Lanzhou from 2011 to 2019 was collected, the method of survival was used analysis and Bayesian Cox Proportional Hazard Regression Model was constructed to analyze the related factors of death.
Results
2
A total of 2 312 HIV/AIDS patients were selected in this study, including 45 AIDS-related deaths. The results of multivariate regression showed that the older the patients were, the higher the risk of death was; the risk of death of AIDS patients at the time of diagnosis was 13.91 times higher than that of HIV-infected patients; Patients who received CD4 testing had a lower risk of death than those who did not; The risk of death was 0.22 times higher among those who received antiretroviral therapy than those who did not receive antiretroviral therapy.
Conclusions
2
Age at diagnosis, course of disease, antiviral therapy were the influencing factors of AIDS-related death in HIV/AIDS patients in Lanzhou. Therefore, it is necessary to strengthen health education for AIDS-related groups, advocate early detection, early diagnosis, and early treatment, expand the coverage of AIDS testing and treatment, prolong the survival time of AIDS patients.
Wang L , Zhang QY , Yang XJ , et al . Analysis of death causes of 245 AIDS patients in Yunnan province [J]. Infect Dis Inf , 2020 , 33 ( 6 ): 513 - 516 .
Huang JY . The analysis of epidemiological characteristics of HIV/AIDS cases reported in Wuhan from 2016 to 2019 [D]. Huazhong University of Science and Technology , 2020 .
Chen JJ , Wang YH , Qi YJ , et al . Analysis of epidemics of HIV/AIDS from 2011 to 2017 in Lanzhou city of China [J]. Chin J Viral Dis , 2019 , 9 ( 2 ): 96 - 101 .
Gao WL , Lin H , Liu XN , et al . Evaluation of estimation of prevalence ratio using Bayesian log-binomial regression model [J]. Chin J Epidemiol , 2017 , 38 ( 3 ): 400 - 405 .
Liu YY , Yao TT , Liu HW , et al . Study on Weibull parametric regression model based on Bayesian estimation [J]. Chin J Health Stat , 2020 , 37 ( 5 ): 795 - 799 .
Spiegelhalter D , Thomas A , Best N , et al . Open BUGS User Manual (version 3.2 . 3) [M]. Cambridge : MRC Biostatistics Unit , 2014 .
Zhang JW , Gao WL , Li XC , et al . Study of Bayesian estimation methods for Cox proportional risk regression models [J]. Chin J Health Stat , 2017 , 34 ( 6 ): 999 - 1001 .
Liu JX , Zhang Y , Tian DZ , et al . Survival status and influencing factors of people living with HIV/AIDS in Dazhu county of Sichuan province from 2007 to 2019 [J]. J Prev Med Inf , 2021 , 37 ( 5 ): 651 - 656 .
Chen J , Xu M , Zhao X , et al . Analysis of the survival conditions of HIV/AIDS patients receiving antiretroviral therapy in Beijing in 2005-2015 and the related factors [J]. Chin J Dis Control Prev , 2018 , 22 ( 12 ): 1225 - 1228 .
Zeng YL , Tang HL , Li JM , et al . Analysis of HIV/AIDS survival in Sichuan province from1991 to 2017 [J]. Chin J Epidemiol , 2019 , 40 ( 3 ): 309 - 314 .
Cui WG , Hu QH , Li H , et al . Efficacy of anti-HIV treatment and drug-resistance mutations in Henan province, China [J]. Chin J Public Health , 2009 , 25 ( 10 ): 1218 - 1219 .
Kitahata MM , Gange SJ , Abraham AG , et al . Effect of early versus deferred antiretroviral therapy for HIV on survival [J]. N Engl J Med , 2009 , 360 ( 18 ): 1815 - 1826 .
Zhang J , Zhang LY , Ouyang Y . The expression and significance of CD83 and Th17 / Treg cells in peripheral blood and bronchoalveolar lavage fluid of mice with chronic obstructive pulmonary disease [J]. J Zunyi Med Univ , 2022 , 45 ( 4 ): 457 - 462 .