The Brain Structure Volume Estimation Based on Synthetic MRI in Pediatric Acute Lymphoblastic Leukemia

HOU Wei-feng; SU Shu; CHEN Ying-qian; QIAN Long; TANG Yan-lai; HUANG Li-bin; YANG Zhi-yun; LIN Li-ping

doi:10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0211

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The Brain Structure Volume Estimation Based on Synthetic MRI in Pediatric Acute Lymphoblastic Leukemia

Clinical Research | 更新时间：2024-02-19

- The Brain Structure Volume Estimation Based on Synthetic MRI in Pediatric Acute Lymphoblastic Leukemia
- Journal of Sun Yat-sen University(Medical Sciences) Vol. 44, Issue 2, Pages: 271-276(2023)
- 作者机构：
  
  1.中山大学附属第一医院放射科，广东广州，510080
  2.GE医疗磁共振科研部，北京100020
  3.中山大学附属第一医院儿科，广东广州，510080
- 作者简介：
  
  LIN Li-ping； E-mail： linlp5@mail2.sysu.edu.cn
- 基金信息：
- DOI：10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0211
  CLC： R445.2
- Received：18 October 2022，
  
  Published：20 March 2023
- 稿件说明：
移动端阅览
候威锋,苏舒,陈颖茜等.基于集成磁共振成像的急性淋巴细胞性白血病儿童脑体积测量[J].中山大学学报（医学科学版）,2023,44(02):271-276.

HOU Wei-feng,SU Shu,CHEN Ying-qian,et al.The Brain Structure Volume Estimation Based on Synthetic MRI in Pediatric Acute Lymphoblastic Leukemia[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(02):271-276.
候威锋,苏舒,陈颖茜等.基于集成磁共振成像的急性淋巴细胞性白血病儿童脑体积测量[J].中山大学学报（医学科学版）,2023,44(02):271-276. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0211.

HOU Wei-feng,SU Shu,CHEN Ying-qian,et al.The Brain Structure Volume Estimation Based on Synthetic MRI in Pediatric Acute Lymphoblastic Leukemia[J].Journal of Sun Yat-sen University(Medical Sciences),2023,44(02):271-276. DOI： 10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2023.0211.

摘要

目的

儿童急性淋巴细胞性白血病（ALL）常发生中枢神经系统（CNS）浸润。ALL患儿多表现出亚临床CNS浸润，常规方法难以早期检测。本研究旨在探讨基于集成磁共振成像（Sy MRI）脑容量参数在临床未检测出CNS浸润的ALL患儿中的变化。

方法

前瞻性收集ALL患儿36例和典型发育（TD）儿童29例，所有被试均行Sy MRI检查。使用Synthetic MR软件后处理并获得总白质体积、灰质体积、脑脊液体积等脑容量参数，用协方差分析评估组间差异。采用Spearman相关性分析探讨生物学特征与有统计学意义的脑容量参数的相关性。

结果

与TD儿童相比，ALL患儿的脑脊液体积增加（

FDR校正

= 0.009）及灰质体积减小（

FDR校正

= 0.027）。ALL患儿灰质体积/颅内体积与危险度分级呈中度负相关（

= -0.380，

= 0.022）。

结论

临床未检测出CNS浸润的ALL患儿表现为脑脊液蓄积及灰质减少。这些新发现提示ALL患儿CNS浸润亚临床期的脑容量的变化，为探究ALL患儿CNS浸润的潜在机制及早期诊断提供新的方向。

Abstract

Objective

Central nervous system （CNS） infiltration commonly occurs in children with acute lymphoblastic leukemia （ALL）. Early subclinical CNS infiltration in pediatric ALL is hard to detect with conventional methods. This study aimed to investigate the changes of brain structure volume parameters based on Synthetic MRI （SyMRI） in pediatric ALL without clinically diagnosed CNS infiltration.

Methods

Thirty-six ALL and twenty-nine typically developing （TD） children were prospectively collected and all underwent SyMRI. The Synthetic MR software was used to obtain brain volumetric parameters including total white matter volume （WMV）， gray matter volume （GMV）， cerebrospinal fluid （CSF） volume， etc. and their within-group differences were assessed by analysis of covariance. The Spearman correlation analysis was used to examine the correlation between biological characteristics and statistically significant brain volume parameters.

Results

ALL children showed increased CSF volume （

FDR-corrected

= 0.009） and decreased GMV （

FDR-corrected

= 0.027） when compared to TD children. We also found a moderately negative association between GMV/intracranial volume and risk classification in pediatric ALL （

= -0.380，

= 0.022）.

Conclusions

Pediatric ALL without clinically diagnosed CNS infiltration presented with accumulation of CSF and reduction of gray matter. The brain volumetric changes in subclinical CNS infiltration of pediatric ALL provides a new attempt for exploring the underlying mechanism and early detection of CNS infiltration in pediatric ALL.

关键词

Keywords

references

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Related Author

DAI Yan

CHEN Ying-qian

SU Shu

QIAN Long

WU Liu-hui

ZHANG Hong-yu

FAN Miao

YANG Zhi-yun

Related Institution

Department of Radiology , The First Affiliated Hospital, Sun Yat-sen University

Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University

MR Research,GE Healthcare

Department of Respiratory Medicine， Children's Hospital of Chongqing Medical University//National Clinical Research Center for Child Health and Disorders//Ministry of Education Key Laboratory of Child Development and Disorders//Chongqing Key Laboratory of Child Infection and Immunity

Department of Radiology， Children's Hospital of Chongqing Medical University//National Clinical Research Center for Child Health and Disorders//Ministry of Education Key Laboratory of Child Development and Disorders//Chongqing Key Laboratory of Child Infection and Immunity

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